Articles

O.03 DETECTION OF AR PERTURBATIONS IN CIRCULATING TUMOUR CELLS AND CELL-FREE DNA FROM PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER PREDICTS RESISTANCE TO ENDOCRINE THERAPY

BJMO - 12, issue 3, february 2018

B. De Laere PhD, Markus Mayrhofer , T. Whitington , P-J. Van Dam MD, P. Van Oyen , C. Ghysel , J. Ampe , P. Ost MD, PhD, Wim Demey MD, L. Hoekx MD, D. Schrijvers MD, PhD, B. Brouwers MD, PhD, W. Lybaert MD, E. Everaert , P. Van Kerckhove , D. De Maeseneer MD, M. Strijbos MD, PhD, A. Bols MD, PhD, K. Fransis , Nick Beije , Inge De Kruijff , S. Oeyen , A. Rutten MD, V. Van Dam , A. Brouwer , D. Goossens , Lien Heyrman , G. Van Den Eynden MD, PhD, J. Vandebroek , Jurgen Del-Favero , S. Sleijfer , A. Uhlen , Jeffrey Yachnin , S. Van Laere PhD, Henrik Grönberg , Johan Lindberg , L. Dirix MD

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Study on tumour biology and the aging effect of chemotherapeutic treatment in older breast cancer patients

BJMO - volume 12, issue 1, february 2018

B. Brouwers MD, PhD

Summary

The main objective of this doctoral research was to expand the scientific knowledge on the complex interface between cancer and biological aging. In the first part, we started by studying stromal characteristics of breast cancers arising in young respectively old patients. Differences in stroma, could lead to a different behaviour of the tumour cells according to age. By laser capturing the stromal compartments of breast cancers from young and old patients, and comparing the gene expression profiles, we confirmed for the first time in humans, the presence of a Senescence Associated Secretory Profile and of Autophagy to Senescence Transition in older breast cancer stromal samples as well as differences in gene expression mainly in genes responsible for proliferation, dedifferentiation and migration into the extracellular matrix.

In the second part of the thesis, we investigated biological aging in the rest of the organism, and the impact from cancer treatment (by chemotherapy) on this process. In a retrospective study investigating several biological and clinical parameters of aging in young and old breast cancer patients, IL-6 showed to be a robust frailty marker. Next, we performed a prospective study in early breast cancer patients either or not treated with adjuvant chemotherapy, and tested if the natural evolution of clinical and/or biological aging markers was influenced by chemotherapy. We did not find convincing evidence that chemotherapy would accelerate biological aging in breast cancer patients.

(BELG J MED ONCOL 2018;12(1):29–32)

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O.01 Circulating Tumour Cells and Survival in Abiraterone- and Enzalutamide-treated Patients with Castration-Resistant Prostate Cancer

BJMO - 2017, issue 3, february 2017

B. De Laere PhD, P. Van Oyen , C. Ghysel , P. Ost MD, PhD, Wim Demey MD, L. Hoekx MD, D. Schrijvers MD, PhD, B. Brouwers MD, PhD, W. Lybaert MD, E. Everaert , J. Ampe , P. Van Kerckhove , D. De Maeseneer MD, M. Strijbos MD, PhD, A. Bols MD, PhD, K. Fransis , S. Oeyen , V. Van Dam , A. Brouwer , G. Van Den Eynden MD, PhD, A. Rutten MD, J. Vandebroek , S. Van Laere PhD, L. Dirix MD

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