BJMO - 2021, issue 3, march 2021
Rafael Caparica , Elisa Agostinetto , Lucas Vian , Marco Bruzzone , Marcello Ceppi , Noam Ponde , Matteo Lambertini , Evandro de Azambuja
Introduction/aim: The combination of CDK4-6i and endocrine therapy (ET) is standard-of- care for pts with HR+/HER2- advanced breast cancer. However, studies evaluating adjuvant CDK4-6i provided contradictory results thus far. We conducted a systematic review and meta-analysis to assess if the addition of CDK4-6i to adjuvant ET impacts on survival’s outcomes and safety of pts with HR+/HER2- EBC.
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