Squamous cell carcinoma is a malignant neoplasm of squamous cell of the epidermis, it has the potential for rapid growth and a low but significant risk of metsastasis and death. Chronically injured skin is one of the risk factors for the development of cutaneous Squamous cell carcinoma.

Hereby, we describe the case of a 44-year old woman who had a right breast prosthesis with many surgical re-interventions for aesthetic reasons, at least eight operations were done over nine years complicated each time by superimposed infections at the site of the interventions.

During the last procedure, skin biopsies revealed keratinizing, well-differentiated squamous cell carcinoma, tumor was infiltrating the lower quadrants of the breast, and deeply infiltrating the 3rd, 4th and 5th ribs along with lymph nodes involvement (axillary and internal mammary chain).

Six cycles of Carboplatine with Paclitaxel were received as neoadjuvant chemotherapy but unfortunately the fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed a disease progression; subsequently we decided to go for surgical resection planned in the upcoming two weeks.