From the 6th – 10th of December, San Antonio, TX was again transformed into the world’s capital in the fight against breast cancer. The Cancer Therapy & Research Center (CTRC) and the American Association for Cancer Research (AACR) were the joint organisers of this 34th edition of the San Antonio Breast Cancer Symposium. This year’s meeting attracted nearly 8,000 participants from over 90 countries and again proved to be the number 1 breast cancer meeting in the world. This report does not aim to summarise the entire meeting but aims at discussing the highlights of the meeting. (BELG J MED ONCOL 2011;6:73–76)