Table of Contents:

• PI3K inhibitors in medical oncology: Update on an emerging treatment Modality
• Indications and timing of neurosurgery for brain metastases in NSCLC
• Guidelines for the detection of NTRK fusions. A report from the Belgian Molecular Pathology Working Group
• Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer: Is radiotherapy worthwhile?
• A case of HER2-positive breast cancer with rapidly progressing CNS metastases
• Paving the way for immunotherapy in pancreatic cancer by exploring a novel combination immunotherapy consisting of a CD40 agonist and interleukin-15
• New oncology reimbursements in Belgium