During the 2025 annual BSMO meeting, an entire session was dedicated to the recent advances in rare cancers. In a first lecture of the session, Dr. Patrick Schöffski (University Hospitals Leuven) selected highlights on sarcoma. Next, Dr. Willem Lybaert (VITAZ/UZA) summarised the latest clinical updates in the treatment of neuroendocrine tumours. Finally, Dr. Pierre Frères (CHU de Liège) provided an overview of the latest findings in the management of glioblastoma.