BJMO - volume 19, issue 6, october 2025
E. Peys MD, K. De Muynck MD, E. De Droogh MD, D. Galdermans MD, D. Schrijvers MD, PhD, C. Deroose MD, PhD
Atypical carcinoid tumours (AC) of the lung are rare neuro-endocrine neoplasms (NENs). Peptide Receptor Radionuclide Therapy (PRRT) has emerged as a pivotal treatment for advanced NENs, that can also be used for bronchial NENs. It makes use of the overexpression of somatostatin receptors (SSTR) to deliver targeted radiation. This report highlights a case of pneumonitis following PRRT in a patient with metastatic AC, underscoring its distinction from radiation pneumonitis (RP).
(BELG J MED ONCOL 2025;19(6):296–299)
Read moreBJMO - volume 19, issue 1, january 2025
E. De Smet MA, D. Schrijvers MD, PhD, K. De Muynck MD, A. Vandebroek MD, E. De Droogh MD
This case report describes a sarcoid like reaction (SLR) in a patient with HER2-positive breast cancer undergoing treatment with trastuzumab and pertuzumab. SLRs are granulomatous reactions characterized by non-caseating epithelioid granulomas that can occur in cancer patients in response to infection, malignancy, or drugs. If found they have the potential to complicate radiological interpretations, mimic disease progression and challenge treatment evaluation. In HER2-positive breast cancer treated with trastuzumab, drug-induced SLRs have been reported, although not commonly. Clinicians should be aware of this entity, and when in doubt, tissue biopsy is needed to avoid misdiagnosis.
((BELG J MED ONCOL 2025;19(1):32–35)
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