Articles

O.10 Cardiotoxicity of immune checkpoint inhibitors (ICI): a systematic review and meta-analysis of randomized clinical trials

BJMO - 2021, issue 3, march 2021

Elisa Agostinetto , Daniel Eiger , Matteo Lambertini , Marcello Ceppi , Marco Bruzzone , Noam Ponde , Chris Plummer , Ahmad Hussein Awada , Martine Piccart-Gebhart , Evandro de Azambuja

Introduction: ICI can cause potentially life-threatening adverse events (AE) and their risk of cardiotoxicity has been poorly investigated. It is also unknown whether ICI combinations increases cardiotoxicity compared to single ICI. We aimed to assess the cardiotoxicity rate of ICI compared to other cancer treatments (primary objective) and of dual-agent ICI (immunotherapy combinations) compared to single-agent ICI (secondary objective).

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O.11 Cyclin dependent kinase inhibitors (CDK4-6i) as adjuvant treatment for patients (pts) with hormone receptor-positive (HR+)/HER2-negative (HER2-) early breast cancer (EBC): a systematic review and meta-analysis

BJMO - 2021, issue 3, march 2021

Rafael Caparica , Elisa Agostinetto , Lucas Vian , Marco Bruzzone , Marcello Ceppi , Noam Ponde , Matteo Lambertini , Evandro de Azambuja

Introduction/aim: The combination of CDK4-6i and endocrine therapy (ET) is standard-of- care for pts with HR+/HER2- advanced breast cancer. However, studies evaluating adjuvant CDK4-6i provided contradictory results thus far. We conducted a systematic review and meta-analysis to assess if the addition of CDK4-6i to adjuvant ET impacts on survival’s outcomes and safety of pts with HR+/HER2- EBC.

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P15 Impact of pandemic Covid19 on Multidisciplinary Tumor Board in Breast Cancer around the world

BJMO - 2021, issue 3, march 2021

Sofia Cristovao Ferreira , Rita Saude Conde , Mariana Brandao , Gil Morgan , Evandro de Azambuja

Introduction: Pandemic Covid19 had an important impact on health care systems worldwide. Multidisciplinary tumour boards (MTB) are considered essential to provide the best care to cancer patients. The aim of this study is to evaluate the impact of Covid19 in Breast Cancer (BC) MTB worldwide.

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