Articles

MicroRNA as predictive biomarkers for drug resistance and sensitivity in colorectal cancer

BJMO - volume 11, issue 1, february 2017

G. Li PhD, A. Cavazzoni PhD, E. Giovannetti MD, PhD, M. A. Barbera MD, G. Frega MD, G. Biasco MD, I. Garajová MD, PhD

SUMMARY

Despite significant improvement in anticancer treatment options, many patients are resistant or develop secondary resistance to anticancer agents, highlighting the necessity for seeking novel predictive markers for drug resistance. Piling evidence has identified miRNAs as predictive markers for resistance/sensitivity to chemotherapy and anti-VEGF/anti-EGFR monoclonal antibody therapy in colorectal cancer patients. In this review, we summarise the current knowledge of the role of miRNAs as possible response predictors to current anticancer treatments for metastatic colorectal cancer patients.

(BELG J MED ONCOL 2017;11(1):18–25)

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