Articles

O.12 Systematic review and meta-analysis of febrile neutropenia risk with TCH(P) in HER2-positive breast cancer

BJMO - 2021, issue 3, march 2021

Hannah Van Belle , Hans Wildiers

Background: Docetaxel, carboplatin and trastuzumab, with or without pertuzumab (TCH(P)), is increasingly used for (neo) adjuvant treatment of HER2-positive early breast cancer. However, its associated febrile neutropenia (FN) risk is unclear: pivotal studies reported FN risks <10%, but in clinical practice a high FN rate (>20%) was observed. This systematic review and meta-analysis determine the FN risk associated with TCH(P) and the effect of primary prophylactic granulocyte colony-stimulating factor (PP G-CSF).

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