Hans Wildiers

O.12 Systematic review and meta-analysis of febrile neutropenia risk with TCH(P) in HER2-positive breast cancer

Background: Docetaxel, carboplatin and trastuzumab, with or without pertuzumab (TCH(P)), is increasingly used for (neo) adjuvant treatment of HER2-positive early breast cancer. However, its associated febrile neutropenia (FN) risk is unclear: pivotal studies reported FN risks <10%, but in clinical practice a high FN rate (>20%) was observed. This systematic review and meta-analysis determine the FN risk associated with TCH(P) and the effect of primary prophylactic granulocyte colony-stimulating factor (PP G-CSF).

O.19 Overall survival improvement in metastatic clear-cell renal cell carcinoma patients from 2000 to 2020

Introduction: Only a limited number of recent phase III studies with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs), mTOR-inhibitors or immune checkpoint inhibitors (ICI) in metastatic clear-cell renal cell carcinoma (m-ccRCC) could show an overall survival (OS) benefit compared to standard of care. We aimed to study the evolution of OS of m-ccRCC patients during the last 20-years period (2000–2020).

P18 Retrospective analysis of the clinical presentation, treatment and outcome of angiosarcoma in a sarcoma referral center

Objective: Angiosarcoma (AS) is a rare, aggressive subtype of soft tissue sarcoma (STS). Treatment requires a multidisciplinary approach and should preferably be carried out in reference centers. We performed an in-depth analysis of patient characteristics, treatments and prognostic factors in patients (pts) with AS treated at the University Hospitals Leuven (Belgium).

Introduction