Articles

Highlights in hormone-receptor positive breast cancer

BJMO - 2024, issue Special, februari 2024

James Collins PhD, T. Feys MBA, MSc

With respect to hormone receptor positive (HR+) breast cancer, SABCS 2023 featured subgroup analyses of the CheckMate 7FL and KEYNOTE-756 trials evaluating perioperative nivolumab or pembrolizumab in patients with early-stage disease.1,2 Also in early-stage HR+ breast cancer, the final invasive disease free survival (iDFS) analysis of the NATALEE trial was presented evaluating adjuvant ribociclib added to ET.3 In metastatic HR+/HER2- breast cancer, datopotamab deruxtecan was shown to delay disease progression in pre-treated patients.4 In the first line treatment for advanced HR+/HER2- breast cancer, SABCS 2023 featured the overall survival (OS) analysis of the MONARCH-3 trial, while INAVO120 demonstrated a progression-free survival (PFS) benefit for the addition of the PI3Kα inhibitor inavolisib to palbociclib and fulvestrant in patients with PIK3CA-mutated, HR+/HER2- advanced breast cancer.5

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Skin cancer session

BJMO - 2023, issue Special, february 2023

James Collins PhD, T. Feys MBA, MSc

The skin cancer session of the 25th annual meeting of The Belgian Society for Medical Oncology highlighted recent advances in the treatment of patients with melanoma and other skin cancers. Beginning this session, Prof. Dr. Vibeke Kruse (VITAZ – AZ Nikolaas, Sint-Niklaas) discussed adjuvant and neoadjuvant treatments for melanoma. Subsequently, Prof. Dr. Oliver Bechter (University Hospitals Leuven, Leuven) outlined recent findings in metastatic melanoma. Prof. Dr. Jean-Francois Baurain (Cliniques Universitaires St Luc, Brussels) followed up with a ‘survival guide’ for medical oncologists dealing with non-melanoma skin cancer. Dr. Tess van Meerhaeghe (Hôpital Erasme, Cliniques Universitaires de Bruxelles, Brussels) closed the session with an overview of immune checkpoint inhibitors in kidney transplant recipients.

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