Articles

Doublets in the first-line treatment of metastatic renal cell cancer with clear cell histology

BJMO - volume 16, issue 2, march 2022

D. Schrijvers MD, PhD, S. Van Wambeke MD, W. Teurfs MD

SUMMARY

The treatment of mRCC has undergone a tremendous evolution in the last decades. There are data that the doublets of checkpoints inhibitors with each other or with anti-angiogenic agents improve PFS compared to sunitinib alone.

In this article, we review the different combinations and give some guidance for their use.

(BELG J MED ONCOL 2022;16(2):48–52)

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BRCA1 and BRCA2 mutations in prostate cancer: consequences and implications

BJMO - volume 15, issue 6, october 2021

D. Schrijvers MD, PhD, W. Teurfs MD, S. Van Wambeke MD

SUMMARY

BRCA mutations play an important role in prostate cancer. All patients with high-risk localised or metastatic prostate cancer should be tested for somatic mutations and, if present, for germline mutations. BRCA muta-tions translate in a more aggressive prostate cancer with a worse prognosis. If these mutations are present, PARP inhibitors may be part of the treatment strategy.

(BELG J MED ONCOL 2021;15(6):283-5)

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The role of docetaxel in prostate cancer

BJMO - volume 9, issue 5, september 2015

D. Schrijvers MD, PhD, W. Teurfs MD

Docetaxel has shown to improve survival and quality of life in patients with castration-resistant prostate cancer. Its place as first-line treatment in this population is challenged by new hormonal treatments, but it still has a place in this setting. Its role in metastatic hormone-sensitive prostate cancer is becoming clearer and docetaxel may be offered to selected patients. In localised high-risk prostate cancer the place of docetaxel remains to be determined.

(BELG J MED ONCOL 2015;9(5):191–93)

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