Experience from the University Hospitals Leuven: Targeted RNA sequencing for the detection of actionable oncogenic driver mutations in NSCLC

November 2023 Clinical Practice Jolien Blokken

Over the last decade we have witnessed a dramatic evolution in the treatment paradigm for patients with advanced non-small cell lung cancer (NSCLC). In this, targeted therapy has become the standard of care for subgroups of patients harboring specific oncogenic driver alterations. To facilitate an accurate and timely detection of these targetable molecular alterations, hospitals have adopted different strategies to optimize the molecular testing for patients with NSCLC. In this article, Prof. Christophe Dooms (thoracic oncologist), Prof. Birgit Weynand (pathologist) and Prof. Isabelle Vanden Bempt (clinical biologist) discuss how they addressed the challenges posed by the evolving molecular testing needs in patients with NSCLC.

In this interview Prof. Dooms, Prof. Weynand and Prof. Vanden Bempt shared their insights on the following questions:

  • What is the current workflow for molecular testing in patients with NSCLC?
  • What is the turnaround time you are able to achieve with this RNA-based strategy?
  • How do you think the molecular testing landscape for NSCLC patients will evolve in the years to come?

Read the complete interview here

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