Introduction: primary breast lymphoma is a rare malignancy representing less than 1% of all tumours presenting in the breast.
Case report: a 64 year-old woman presented with altered mental status due to severe hypercalcemia and was found to have a large breast mass with lytic bone lesion of the skull. Biopsy of the mass revealed double hit lymphoma.
Conclusion: we discuss a rare case of breast malignancy with atypical clinical presentation and the literature concerning the characteristics and therapeutic options available for double hit lymphomas.
(BELG J MED ONCOL 2017;11(3):122–125)