During the academic session of the BSMO 2025 annual meeting, Dr. Matteo Lambertini (University of Genova – IRCCS Ospedale Policlinico San Martino, Italy) talked about the challenges and opportunities in the care of young patients with cancer, particularly young women with breast cancer. Dr. Martine Piccart (Institute Jules Bordet, Belgium) elaborated on the use of surrogate endpoints and the ESMO-MCBS for drug approval.