Data regarding the natural history of prostate cancer (PCa) disease confirm the clinical insignificance of low-grade prostate cancer, which is associated with scant or no metastatic dissemination. Active surveillance (AS) is a conservative management approach, conducted for patients with “low-” or “favorable-risk” disease, which avoids long-term adverse effects on the patient’s quality of life. In a lecture during BMUC 2018, Prof. de la Taille explained why he thinks that AS is an option that we need to consider and why we should discuss this with the patient before the biopsy is taken.