Amivantamab plus lazertinib as a first-line treatment for patients with EGFR-mutant advanced NSCLC

Since the publication of the ADAURA trial, osimertinib has been the undisputed standard of care first line treatment for patients with advanced, EGFR-mutant non-small cell lung cancer (NSCLC). Despite a high initial response rate with this agent, most patients treated with osimertinib will eventually relapse. During the 2023 annual meeting of the European Society of Medical Oncology (ESMO), results of the randomized, phase 3 MARIPOSA trial demonstrated that a combination of amivantamab and lazertinib was associated with a better progression-free survival (PFS) and more durable responses than osimertinib in previously untreated advanced, EGFR-mutant NSCLC patients. With these findings, amivantamab plus lazertinib challenges osimertinib as the standard of care in this setting.