The 27th annual BSMO (Belgian Society of Medical Oncology) meeting kicked off with the Breast Cancer Task Force. Dr. Yannick Van Herck (University Hospitals Leuven) started the session with a presentation on early recurrence to (neo)adjuvant systemic therapy in triple-negative breast cancer (TNBC). Next, Dr. Andrea Gombos (Institute Jules Bordet) discussed the occurrence of resistance to cyclin dependent kinase 4/6 inhibitors (CDK4/6i) in luminal breast cancer and the optimal treatment choice following CDK4/6i. Finally, Dr. Eline Naert (UZ Ghent) explored the utility of gene expression profiling (GEP) in clinical practice.