Immunotherapy has become a successful modality in the treatment of a number of cancers. Still, generally not more than one third of the patients respond well to this type of therapy. To improve the outcome, researchers are evaluating combinations with other modalities, such as radiotherapy. During BMUC 2019, radiation oncologist dr. Shankar Siva presented the results obtained with local radiotherapy and immunotherapy, and discussed the optimal sequence, timing and dosing of this combination treatment.