The human microbiome was recently associated with different diseases. The explanation for this relationship is however not yet clarified. In this research, the interaction of chemically diverse quorum sensing peptides, produced by the bacteria and summarised in the Quorum peps database, with human cancer cells was explored. We demonstrated that some quorum sensing peptides induced colon and breast cancer cell invasion in vitro and promoted angiogenesis; both processes can be linked to cancer metastasis. Our findings thus indicate that the human microbiome, through their quorum sensing peptides, can be one of the factors responsible for cancer metastasis.

(BELG J MED ONCOL 2017;11(2):75–77)