From the 4–8th of December, the San Antonio Riverwalk again formed the background of the most important breast cancer congress in the world. This report will summarise eight top stories presented during the 2018 San Antonio Breast Cancer Symposium (SABCS). For a more complete overview of studies presented at the meeting, we refer to the congress website

(BELG J MED ONCOL 2019;13(2):66–71)