The 2022 ASCO Annual Meeting was held in Chicago, USA, between the 3rd and 7th of June 2022. The main goal of this overview is to highlight the most striking abstracts in the field of digestive oncology for daily clinical practice. First, the upper gastro-intestinal tract tumours will be discussed, followed by an overview of the congress highlights related to cancers of the lower gastro-intestinal tract.

(Belg J Med Oncol 2022;16(5):223–8)