The European Society of Medical Oncology (ESMO) Congress 2022 was held in Paris, France, between the 9th and 13th of September 2022. The main goal of this overview is to highlight the most relevant findings in the field of digestive oncology that could impact daily clinical practice. First, the upper gastrointestinal tract tumours will be discussed, followed by an overview of the congress highlights related to cancers of the lower gastrointestinal tract.

(Belg J Med Oncol 2022;16(8):412–20)