From June 1st till June 5th, Chicago was host for the 54th ASCO annual meeting. The theme for this year’s venue was ‘Delivering Discoveries: Expanding the Reach of Precision Medicine’. With more than 32,000 oncology professionals from around the world to discuss state-of-the-art treatment modalities, new therapies, and ongoing controversies in the field; this year’s meeting was a great success. This report will highlight 11 key studies concerning genitourinary cancers presented during the meeting.