ESMO Congress 2021 was held from the 16th till the 21st of September, once again in a virtual format. During this congress, more immunotherapy data were shown in the neoadjuvant setting of resectable head and neck cancer, in the concomitant radiotherapy setting and first-line recurrent/metastatic disease. In addition, a nomogram was created for patients undergoing concomitant chemoradiotherapy that can be used as a web-based tool for our clinic. Other data underscore that treatment of elderly patients with a head and neck cancer nowadays require a comprehensive geriatric assessment. In this report, these and other important studies related to head-and-neck cancer will be discussed, together with some comments on the clinical relevance of these findings.

(BELG J MED ONCOL 2021;15(8):421–7)