2012 has been a rich year in progress on cancer care. Many studies highlighted this year capitalised on the growing insight into the complexity of cancer to develop sophisticated treatment approaches, including combinations of targeted drugs for difficult-to-treat cancers and expanded use of targeted drugs to multiple forms of cancer sharing the same genetic alteration. This article is based on the clinical cancer advances 2012 article published by the American Society of Clinical Oncology and lists the most important advances made in the different fields of oncology that are most likely to impact daily clinical practice.1

(BELG J MED ONCOL 2013;7:10–14)