At the background of the Golden Gate Bridge with a view on the Pacific Ocean, the annual Gastrointestinal Cancers Symposium was held from 23rd until 25th January 2020 in the Moscone Congress Center in San Francisco, California. During this meeting, the potential of immunotherapy in the treatment of cancers from the upper and lower digestive tract was discussed, but no major breakthroughs were presented this year. In addition to immunotherapy, ASCO GI 2020 featured several interesting presentations on the molecular profiling of different types of gastro-intestinal cancers. These increased molecular insights will hopefully pave the way for a more biomarker-driven treatment approach for these tumours in the near future. In this report, the most important headlines will be discussed, with comments on the clinical relevance of the different studies.

(BELG J MED ONCOL 2020;14(3):116–25)