Pancreatic adenocarcinoma (PDAC) continues to be one of the most lethal cancers. In recent years, immunotherapy using immune checkpoint inhibitors (ICIs) resulted in dramatic clinical benefits in many solid tumor types. However, PDAC patients are yet to experience the potential benefits of this treatment strategy. This article will provide a brief overview of the available data obtained with ICI-based treatments in patients with advanced PDAC. These studies illustrate that PDACs are inherently immune-cold tumors who are largely refractory to ICI-based therapy in clinical trials. Understanding and overcoming the current failures of immunotherapy through elucidating resistance mechanisms and developing novel therapeutic approaches are essential to harness the potential durable benefits of immune-modulating therapy in this setting.