Primary urethral cancer is an extremely rare and aggressive malignancy. Due to its rarity and the lack of large prospective trials, no standardised treatment protocols are currently available, and treatment decisions are most often made on a case-to-case basis. We present the case of a 62-year-old male with squamous cell carcinoma of the posterior urethra treated at our institution followed by an in-depth discussion on presentation, diagnosis and treatment of this rare cancer.

(BELG J MED ONCOL 2019;13(1):27–30)