Journal issues > Issue 6, October 2017 > Role of glucocorticoid receptor-mediated effects on the colon cancer microenvironment

Role of glucocorticoid receptor-mediated effects on the colon cancer microenvironment

By: Z. Drebert PhD

SUMMARY

The cancer microenvironment, which includes cancer-associated fibroblasts, plays an essential role during cancer progression. Glucocorticoids, steroidal ligands of glucocorticoid receptor, are often administered to cancer patients during chemotherapy. Glucocorticoids have a substantial effect on CAFs, affecting composition of their secretome, which results in a reduced pro-angiogenic effect and a neutralized growth- and invasion-promoting impact on cancer cells.

(BELG J MED ONCOL 2017;11(6):289–291)

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