Over the last 10 years we have witnessed a revolution in the treatment of metastatic castration-resistant prostate cancer (mCRPC). The introduction of several new therapeutic modalities had a significant impact on the overall survival (OS) of these patients. Whereas the median OS for patients with mCRPC was only 24.2 months back in 1997, this has increased to 39.4 months in a patient cohort from 2007 to 2013. This represents an increase in the median OS with 1.5 years.1 Currently, patients with mCRPC have 6 different drugs at their disposal. The question now is: “how to best sequence these different options?”