Over the course of 2020, updates were presented of several pivotal randomised controlled trials in renal cell carcinoma (RCC). During the 2020 annual BMUC meeting, Prof. Dr. Axel Bex (UCL Division of Surgery and Interventional Science, London, UK. The Netherlands Cancer Institute, Amsterdam, The Netherlands) provided an overview of the most important novelties in the field of RCC and gave us a look into the future.