The RANK ligand inhibitor denosumab as novel therapeutic agent in the spectrum of cancer bone disease

BJMO - volume 6, issue 4, september 2012

T. van den Wyngaert MD, PhD, M.T. Huizing

Recently, the monoclonal antibody denosumab has been registered as a new first-in-class treatment option for the prevention of skeletal-related events (SREs) in patients with bone metastases from a solid tumour, for the treatment of treatment-induced bone loss (TIBL) in prostate cancer, and the treatment of post-menopausal osteoporosis. The present article reviews the mechanism of action of denosumab and the research leading to the registered indications in cancer patients. (BELG J MED ONCOL 2012;6:118–123)

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