Journal issues > Issue 4, September 2012 > The RANK ligand inhibitor denosumab as novel therapeutic agent in the spectrum of cancer bone disease

The RANK ligand inhibitor denosumab as novel therapeutic agent in the spectrum of cancer bone disease

By: T. van den Wyngaert MD, PhD, M.T. Huizing

Recently, the monoclonal antibody denosumab has been registered as a new first-in-class treatment option for the prevention of skeletal-related events (SREs) in patients with bone metastases from a solid tumour, for the treatment of treatment-induced bone loss (TIBL) in prostate cancer, and the treatment of post-menopausal osteoporosis. The present article reviews the mechanism of action of denosumab and the research leading to the registered indications in cancer patients. (BELG J MED ONCOL 2012;6:118–123)

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