Colonoscopy with a computer-aided device improves adenoma detection

June 2022 Cancer trials Nalinee Pandey

A recently conducted clinical trial describes that a computer-aided device can improve adenoma detections by 27% in patients undergoing colonoscopy for colorectal cancer (CRC). The findings from this clinical study were published in the Journal Gastroenterology.

It is crucial to improve the efficiency of CRC detection by colonoscopy. Shaukat et al. evaluated the efficacy and safety of a computer-aided device in colonoscopy procedures in a randomised clinical trial.

Study design

The randomised clinical trial enrolled 1,359 patients (aged ≥40 years) who either underwent standard colonoscopy (n=677) or colonoscopy with a computer-aided device (n=682). All the patients were screened for exclusion criteria such as incomplete procedure, diagnostic indication, inflammatory bowel disease, and familial adenomatous polyposis. Basic patient characteristics were well balanced between both treatment groups. The study’s primary endpoints were adenomas per colonoscopy (APC) and true histology rate (THR).


The patients screened with the computer-aided device showed a significant increase in APC (0.85 vs. 0.67 in the standard group, respectively; P=0.018) and ADR (41.3% vs. 38.4%, respectively; P=0.176). In patients who underwent surveillance exams too, the device-aided group showed an increase in APC (1.41 vs. 1.17, respectively, P=0.061) and ADR (59.4% vs. 55.2%, respectively; P=0.196). No significant difference in the THR was observed between the computer device aided group and standard (71.7% vs. 67.4%).


The computer-aided device improved the detection adenoma detection without changing the THR. Future studies with long-term follow-up of patients are needed to expedite the general scope of these findings.


Shaukat A, et al. Computer-Aided Detection Improves Adenomas per Colonoscopy for Screening and Surveillance Colonoscopy: A Randomized Trial. Gastroenterology. 2022 May 25:S0016-5085(22)00519-4.