This PhD thesis is aimed at elucidating some very important issues on high-risk prostate cancer: How can high-risk prostate cancer best be defined? Can we clearly define demarcated prognostic subgroups within the high-risk prostate cancer group which could allow improved patient counselling, comparison of different treatment strategies and proper trial design? What are the outcomes of surgery in high-risk prostate cancer and how can we identify those patients within the heterogeneous group of high-risk prostate cancer who would benefit most from surgery?

(BELG J MED ONCOL 2014;8(5):220–3)